About
Abstract: A so-called adverse outcome pathway (AOP) is a recent toxicological concept proposed to provide a mechanistic representation of biological perturbation over different layers of biological organization at the molecular, cellular and system levels. The perturbation would lead to an adverse outcome at both the population and individual level. Although the concept is independent from a given chemical, some AOPs have nevertheless been proposed with a specific chemical-induced perturbation defined as a stressor. Many chemicals can putatively interfere with an AOP and such information would be relevant for regulatory decision-making.
Contact
Miguel Herrera Bustillo, Bioinformatician: miguel.bustillo [at] cpr.ku.dk
Olivier Taboureau, Professor, PhD: olivier.taboureau [at] paris7.jussieu.fr
Søren Brunak, Professor, PhD: soren.brunak [at] cpr.ku.dk
Translation disease systems biology – Brunak group
The Brunak Group aims for understanding multi-morbidity disease progression patterns and their relation to treatment events. The group integrates heterogeneous life science data from the molecular and clinical domains and is also engaged in methodology of translational utility, such as techniques of relevance within precision medicine.